孝感地区初诊甲状腺疾病患者尿碘水平分析

摘要

目的：通过对孝感地区初诊甲状腺疾病患者的尿碘水平的检测，探讨尿碘水平与甲状腺疾病发生的相关性。方法选择孝感地区160例初诊甲状腺疾病患者作为观察组，同期选择60例健康体检者作为对照组，两组均采用砷铈催化分光光度计法测定尿碘含量，同时采用免疫化学发光法测定血甲状腺功能（ FT3、 FT4、 TSH）及甲状腺抗体（ TGAb、 TMAb）水平，完善两组人群甲状腺彩色超声检查。结果①两组尿碘中位数均＞100μg／L。②观察组尿碘中位数及平均值均明显高于对照组。③观察组中尿碘中位数及平均值均存在由高到低的以下规律：功能亢进组，功能正常组，功能减低组，显示尿碘越高，甲状腺功能水平越高。④观察组随着尿碘水平的增加，甲状腺体积逐渐增大（取肿大明显的单侧比较），但TGAb、 TMAb组间比较无统计学差异。结论尿碘水平的升高是导致初诊甲状腺疾病患者甲状腺功能和形态改变的原因，其与甲状腺自身抗体无明显相关性。孝感地区人群食用普通碘盐后尿碘水平部分过量，需提倡科学补碘。%Objective To investigate the correlation of urinary iodine levels and thyroid disease by detecting the urinary iodine levels of newly diagnosed thyroid disease patients in Xiaogan .Methods 160 patients of newly diagnosed with thyroid disease in Xiaogan were as the observation group , and the 60 healthy within the same period were as the control group .The urinary iodine content was measured by arsenic cerium catalytic spectrophotometry , the blood thyroid function ( FT3, FT4, TSH ) and the thyroid antibodies ( TGAb, TMAb ) level were detected by immune chemiluminescence , and the thyroid color doppler ultrasound examination was also completed .Results ① The median of urinary iodine content of two groups were >100μg/L.②The median and the mean of urinary iodine content in the observation group were significantly higher than the control group .③ The median and the mean of urinary iodine content in the observation group complied with the following rules: hyperthyroidism group , normal group , dysfunction group , showed that the urinary iodine content was positively correlated with the thyroid function level .④ The urinary iodine content was positively correlated with the volume of thyroid ( Taking the obvious swelling side as comparation ) in the observation group , the thyroid antibodies ( TGAb, TMAb) level had no statistical differences between groups .Conclusion The higher urinary iodine content is the reason for the the change of thyroid function and morphology , while the urinary iodine levels has no significant correlation with the thyroid antibodies .The urinary iodine levels is partly excess after eating the general iodized salt for people in Xiaogan , so it is necessary for them to supplement iodine scientifically .