大黄鱼口服硝唑尼特后抗刺激隐核虫感染试验

摘要

将硝唑尼特溶解于二甲亚砜，均匀喷于膨化饲料外涂油膜制成药物饲料，每天按鱼体重的50、100、150 mg·kg－1给药，连续给药6 d。用同步孵出的刺激隐核虫感染子按10000个·尾－1鱼感染鱼体，定期检查鱼体鳃、体表和鳍上滋养体数量。150 mg·kg－1组鱼体经4 d 给药鱼体全部死亡，50、100 mg·kg－1组连续6 d 给药鱼体正常。刺激隐核虫感染子对试验大黄鱼能大量感染，在不同给药量组间及是否给药组间的感染差异不明显，表明大黄鱼口服硝唑尼特不能有效预防刺激隐核虫的感染。%Efficacy of nitazoxanide (NTZ)by oral administration to Pseudosciaena crocea for the Cryptocaryon irritans infection was studied.NTZ was first-dissolved in dimethyl sulfoxide to be sprayed evenly on an extruded fish meal,which was,then,coated with a thin oil film.The meal was fed to the fish every day at the rates of 50, 100 or 150 mg per kg of the fish body weight.The treatments lasted 6 days.At the same time,simultaneously hatched theronts were introduced to infect the fish at a rate of 10 000 per P .crocea.Subsequently,the numbers of trophonts appeared on the gill,skin and fins of each fish were monitored regularly.After the 6-day treatments,all P .crocea were infected with thetheronts in large numbers,and the fish fed with 150 mg·kg-1 diet died,while the others survived.The oral NTZ treatment apparently did not prevent P .crocea from being infected by C.irritans .