目的 了解上海市闵行区2005-2016年梅毒流行病学特征,为制定有效的防治措施提供科学依据.方法 对闵行区2005-2016年报告和监测的梅毒病例资料进行流行病学分析.结果 2005-2016年闵行区共计报告梅毒1 1 394例,发病率42.9/10万,其中Ⅰ、Ⅱ、Ⅲ期、胎传、隐性梅毒发病率分别为10.3/10万、13.4/10万、0.3/100万、2.3/10万、16.6/10万.2009年为发病高峰,发病率为59.1/10万.报告的病例中本辖区人口占62.4％,外省市占37.6％;男性多于女性,男女性别比1.1∶1;25～54岁报告最多,占61.1％,55岁以上年龄组呈明显上升趋势;按户籍分组后,本地以25～64岁为主,占74.2％,男女性别比1.3∶1;外省市以15～44岁为主,占79.1％,男女性别比0.8∶1.女性感染者较男性更为年轻化,15～34岁人群分别占比50.0％和29.3％.本市55岁以上男性、25～54岁女性及外省市15～44岁女性以隐性梅毒为主;本地55岁以下、外省市65岁以下男性以Ⅰ期、Ⅱ期梅毒为主.户籍、性别、年龄、梅毒类型两两经x2检验,差异均有统计学意义(P＜0.001).结论 上海市闵行区梅毒发病趋势呈先上升后下降并趋缓,需加强监测,加大宣传力度,加强对女性及本市老年人口梅毒的主动筛查力度,控制梅毒的蔓延和传播.%Objective To understand the trends and epidemiological characteristics of syphilis in Minhang District of Shanghai,so as to provide scientific basis for making control strategies.Methods The data of reported cases of syphilis in Minhang District from 2005 to 2016 were analyzed with epidemiological methods.Results Overall 11 394 cases of syphilis were reported from 2005 to 2016,the incidence was 42.9 per 100 000 person-year.The incidences of Phase Ⅰ,Phase Ⅱ,Phase Ⅲ,genital and latent syphilis were 10.3,13.4,0.3,2.3 and 16.6 per 100 000 person-year,respectively.In 2009,the incidence reached 59.1 per 100 000 person-year and reach peak.The cases were constituted by local residents (62.4％) and residents from other provinces (37.6％),male patients predominated with male/female ratio of 1.1∶1.Most cases were aged from 25 to 54 years old(61.1 ％),and those people older than 54 years were more and more likely to be found infected.Local residents predominated by those who aged 25-64 years (74.2％) and other province predominated by 15-44 years (79.1％),the ratios of male/female were 1.3 ∶ 1 and 0.8 ∶ 1.Female were much younger than male,there were 50.0％ of female and 29.3％ of male who were aged between 15-34 years old.Latent syphilis was mostly reported in local male residents who were older than 55 years,female who were 25-54 years and other provinces' female aged 15-44.Phase Ⅰ and Ⅱ syphilis were mostly reported in local male residents less than 55 years old and other provinces' male less than 65 years old.There were significant difference between residence,sex,age and different kinds of syphilis with P＜0.001.Conclusions The trends of syphilis incidence was increasing before 2009 in Minhang District and then declining and slowing down in recent years.The measure of reinforcing monitor,propaganda and education,active screening syphilis in female and local old man should be taken to control and prevent the spread of syphilis.
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