醋酸亮丙瑞林微球联合体外受精-胚胎移植治疗子宫腺肌病合并不孕症的疗效观察

摘要

OBJECTIVE:To investigate the clinical leuprolide acetate microspheres combined with IVF -ET in treatment of adenomyosis complicated with infertility .METHODS: 120 patients with adenomyosis complicated with infertility admitted from Jan .2014 to Jan.2015 were selected to be divided into observation group and control group via the random number table , with 60 cases in each .The observation group were treated with leuprolide acetate microspheres combined with in vitro fertilization and embryo transfer ( IVF-ET ) , while the control group only received IVF-ET, the efficacy of two groups were observed and recorded .RESULTS:After treatment , the uterine volume of observation group were significantly less than that before treatment , and significantly less than the control group , the difference was statistically significant ( P0.05).Of the two group of patients, the rate of fertilized eggs, dual nuclear rate and high-quality embryo rate in pregnancy success patients were higher than those of pregnancy failure patients , with significant difference ( P0.05 ) .CONCLUSIONS:Leuprolide acetate microspheres combined with IVF-ET in treatment of adenomyosis complicated with infertility can significantly improve the assisted reproductive effects with clinical significant advantages .It is worthy to be popularized .%目的：探讨醋酸亮丙瑞林微球联合体外受精-胚胎移植（ in vitro fertilization and embryo transfer ，IVF-ET）治疗子宫腺肌病合并不孕症的临床疗效。方法：选择2014年1月—2015年1月收治的120例子宫腺肌病合并不孕症患者，按随机数字表法分为观察组和对照组，每组各60例。观察组患者给予醋酸亮丙瑞林微球排卵联合IVF-ET治疗，对照组单独进行IVF-ET治疗，观察并记录2组患者的疗效。结果：治疗后，观察组患者的子宫体积明显小于治疗前，且明显小于对照组，差异均有统计学意义（ P＜0.05）。观察组患者促性腺激素平均使用时间明显长于对照组，平均使用量明显高于对照组，差异均有统计学意义（ P＜0.05）；观察组患者获卵数和优质胚胎数明显少于对照组，差异有统计学意义（P＜0.05）；2组患者受精率的差异无统计学意义（P＞0.05）；2组患者临床结局的差异无统计学意义（ P＞0.05）。2组患者中，妊娠成功者的受精卵、双源核以及优质胚胎率均高于妊娠失败者，差异有统计学意义（ P＜0.05），但2组的差异无统计学意义（ P＞0.05）。结论：醋酸亮丙瑞林微球联合IVF-ET治疗子宫肌腺病合并不孕症，可显著提升助孕效果，临床优势显著，值得推广。