乳酸菌阴道胶囊联合甲硝唑栓对滴虫性阴道炎患者阴道pH及复发情况的影响

摘要

目的:探讨乳酸菌阴道胶囊联合甲硝唑栓对滴虫性阴道炎患者阴道pH及复发情况的影响.方法:选取2014年10月—2016年10月南阳医学高等专科学校第一附属医院收治的滴虫性阴道炎患者87例作为研究对象,以随机数字表法分为观察组44例和对照组43例.对照组患者给予甲硝唑栓0.5 g,观察组患者在对照组的基础上加用乳酸菌阴道胶囊0.25 g,两组患者均治疗10 d.观察两组患者的临床疗效、阴道pH变化及治疗结束后3、6个月的复发情况.结果:观察组患者的总有效率为90.91％(40/44),明显高于对照组的74.42％(32/43),差异有统计学意义(P<0.05);治疗后,观察组患者平均阴道pH为(4.20±0.25),明显小于对照组的(5.70±0.21),差异有统计学意义(P<0.05);治疗后3、6个月,观察组患者的复发率分别为2.27％(1/44)、0(0/44),明显低于对照组的18.60％(8/43)、16.28％(7/43),差异均有统计学意义(P<0.05).结论:乳酸菌阴道胶囊联合甲硝唑栓治疗滴虫性阴道炎的疗效显著,可降低患者阴道pH和复发率.%OBJECTIVE:To probe into the effects of Lacidophilin vaginal capsules combined with metronidazole suppositories on vaginal pH value and prognosis recurrence rate in patients with trichomonas vaginitis .METHODS:87 patients with trichomonas vaginitis admitted into the First Affiliated Hospital of Nanyang Medical College from Oct . 2014 to Oct.2016 were extracted to be divided into observation group (44 cases) and control group (43 cases) via the random number table .The control group received 0.5 g metronidazole suppositories , while the observation group was additionally given 0.25 g Lacidophilin vaginal capsules based on the control group , the treatment course was 10 d in both groups .The clinical efficacy , changes of vaginal pH value and recurrence rate after treatment of 3 and 6 months in two groups were observed .RESULTS: The total effective rate of observation group was 90.91％ ( 40/44 ) , significantly higher than that of control group [ 74.42％ ( 32/43 ) ] , with statistically significant difference ( P <0.05 ) .After treatment , the average vaginal pH value of observation group was ( 4.20 ±0.25 ) , significantly lower than that of control group (5.70 ±0.21), with statistically significant difference(P<0.05).After treatment of 3 and 6 months, the recurrence rates of observation group were respectively 2.27％(1/44) and 0(0/44), significantly lower than those of control group [18.60％(8/43) and 16.28％(7/43)], with statistically significant difference (P<0.05). CONCLUSIONS:The efficacy of Lacidophilin vaginal capsules combined with metronidazole suppositories in treatment of trichomonas vaginitis is significant , which can reduce the vaginal pH value and recurrence rate of patients .