替罗非班、阿司匹林与氯吡格雷联合用于急性心肌梗死患者急诊经皮冠状动脉介入治疗的效果观察

摘要

OBJECTIVE:To probe into the application effects of tirofiban combined with aspirin and clopidogrel in treatment of percutaneous coronary intervention in patients with acuratemyocardial infarction.METHODS:84 patients with acurate myocardial infarction admitted into the Second People's Hospital of Jiyuan from Jun.2015 to Jun.2016 were selected and divided into observation group and control group via random number table,with 42 cases in each group.The control group was treated with aspirin and clopidogrel,while the observation group was given tirofiban combined with aspirin and clopidogrel.Various indexes,results of coronary angiography,incidence of adverse drug reactions and complications were observed.RESULTS:After treatment,the blood platelet count,maximum platelet aggregation rate and maximum platelet aggregation time induced by adenosine diphosphate of the observation group were significantly lower than those of the control group;the TIMI grading,Blush grading and CTFC of coronary artery blood of the observation group were significantly better than those of the control group,with statistically significant difference(P<0.05);the incidence of adverse drug reactions and complications of the observation group were respectively 7.14％(3/42)and 11.90％(5/42),which were significantly lower than those of the control group [23.81％(10/42),28.57％(12/42)],with statistically significant difference in comparison between groups(P<0.05).CONCLUSIONS:The efficacy of tirofiban combined with aspirin and clopidogrel in treatment of percutaneous coronary intervention in patients with acurate myocardial infarction is remarkable,with less adverse drug reactions and high safety.%目的:探讨替罗非班、阿司匹林与氯吡格雷联合用于急性心肌梗死患者急诊经皮冠状动脉介入治疗的效果.方法:选取2015年6月-2016年6月济源市第二人民医院收治的具有经皮冠状动脉介入治疗指征的急性心肌梗死患者84例作为研究对象,以随机数字表法分为观察组和对照组,每组42例.对照组患者给予阿司匹林与氯吡格雷治疗,观察组患者给予替罗非班、阿司匹林与氯吡格雷联合治疗.观察两组患者各项指标、冠状动脉造影结果、不良反应及出血并发症发生情况.结果:治疗后,观察组患者血小板计数和二磷酸腺苷诱导的血小板最大聚集率、最大聚集时间明显低于对照组;观察组患者冠状动脉血流心肌梗死静脉溶栓分级、Blush分级、校正的心肌梗死溶栓试验帧数明显优于对照组,差异均有统计学意义(P<0.05);观察组患者不良反应发生率及出血并发症发生率分别为7.14％(3/42)、11.90％(5/42),明显低于对照组的23.81％(10/42)、28.57％(12/42),差异均有统计学意义(P<0.05).结论:替罗非班、阿司匹林与氯吡格雷联合用于急性心肌梗死患者急诊经皮冠状动脉介入治疗的效果显著,不良反应少,安全性高.