首页> 中文期刊> 《工程(英文)》 >Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies

Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies

         

摘要

膝关节骨性关节炎(OA)是世界上最常见的关节炎,其发病率逐年上升。不断上涨的治疗费用给患者带来了经济负担。膝关节OA治疗的两个早期干预目标是减轻膝关节的疼痛和关节软骨的损害。目前用于治疗膝关节OA的方法虽取得了一定疗效,但仍没有一种方法可达到全膝关节置换术(TKA)的治疗效果。TKA主要应用于治疗末期膝关节OA,其缺点是有手术侵入性和手术费用昂贵。因而,应该重视创新性的再生技术,以推迟甚至消除患者对TKA的需求。一些基于生物材料和细胞的疗法目前正处于发展阶段,并已在临床前和临床研究方面取得了初步进展。单独或联合应用先进的生物材料和干细胞治疗膝关节OA可减轻疼痛,使损害的关节软骨再生。在此综述中,我们讨论了膝关节OA疼痛和软骨损害的发病机制,并探讨了该病的最新治疗策略及其局限性。

著录项

  • 来源
    《工程(英文)》 |2017年第001期|P.16-27|共12页
  • 作者单位

    [1]Institute for Regenerative Engineering, University of Connecticut Health Center, Farrnington, CT 06030, USA;

    [2]Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA;

    [3]Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA;

    [4]Department of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, CT 06269, USA;

    [5]Department of Materials Science and Engineering, School of Engineering, University of Connecticut, Storrs, CT 06269, USA;

    [6]Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA;

    [7]Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CF 06030, USA;

    [8]Department of Chemical and Biomolecular Engineering, School of Engineering, University of Connecticut, Storrs, CT 06269, USA;

  • 原文格式 PDF
  • 正文语种 CHI
  • 中图分类
  • 关键词

获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号