慢性丙型肝炎患者血清趋化因子CXCL12、CXCL10、CXCL8的检测及其临床意义

摘要

目的：分析趋化因子CXCL12、CXCL10、CXCL8与丙型病毒性肝炎进展的关系。方法：研究分为慢性丙型肝炎、丙型肝炎相关性肝硬化、丙型肝炎相关性肝癌、正常对照组四组，分别收集44例患者、31例患者、12例患者、15例患者的血清，检测每份血清中CXCL12、CXCL10、CXCL8的水平，分析三组患者中CXCL12、CXCL10、CXCL8的水平的差异。结果：慢性丙型肝炎、肝硬化、肝癌患者中CXCL12、CXCL10、CXCL8的水平差异无统计学意义(P>0.05)，但三组患者的CXCL12、CXCL10、CXCL8浓度与正常对照组比较均具有统计学差异(P<0.05)。结论：趋化因子CXCL12、CXCL10、CXCL8水平与丙型肝炎病毒(HCV)感染密切相关，但不能作为丙型肝炎患者疾病进展的预测因素。%Objective:To analysis the relationship between chemokine CXCL12,CXCL10,CXCL8 and progress of hepatitis C. Methods:Forty-four patients,thirty-one patients, twelve patients and iffteen patients were assigned to the chronic hepatitis C group, hepatitis C related cirrhosis group, hepatitis C related liver cancer group and normal control group, respectively. Serum CXCL12,CXCL10,CXCL8 were measured in each patient. Level of CXCL12,CXCL10,CXCL8 in three groups were compared.Results:There was no difference in the level of CXCL12,CXCL10,CXCL8 among three groups(P>0.05),but significant difference compared with normal control group(P<0.05). Conclusion:Chemokine CXCL12,CXCL10,CXCL8 are closely correlated with HCV infection, but not as a predictor of disease progression in hepatitis C patients.