Introduction: The Moufarrege total posterior pedicle breast reduction involves complete denudation of the breast offering free access to all breast quadrants. This allows a total resection of the upper outer quadrant which is most implicated in breast cancer. The objective was to assess the postoperative incidence of breast cancer in the cohort of women who underwent the Moufarrege technique. Methods: Retrospective chart review was performed for patients operated on between 1981 and 1997, and a written questionnaire was sent to all patients in 2008. Patients were asked about the date of their last mammogram and any diagnosis of breast cancer. Expected numbers of cancers were calculated from rates in the general population. Age standardization at the time of surgery was done and the incidence of breast cancer was calculated in relation to age at time of surgery and age at last follow-up. Results were presented as standardized incidence ratios (SIR) with their corresponding 95% confidence interval (CI). Results: We included 924 patients. The response rate was 60.38% (n = 558). Mean patient age at the time of the surgery was 32.8 years (14 to 82). Mean resection weight was 620 grs per breast (250 - 1600). Breast cancer was significantly reduced by nearly 64 percent in patients who responded to our questionnaire and were aged 35 years or more at the time of surgery ([SIR] = 0.36;95 % [CI] 0.09 - 0.93). No difference in breast cancer incidence was observed in patients aged less than 25 years at the time of the surgery. Conclusion: The Moufarrege Total Posterior Pedicle breast reduction is a reliable and safe procedure that may offer a superior breast cancer risk reduction based on the results of our retrospective chart review and patient questionnaire.
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