基于矩阵图谱表达法的蛋白质序列的相似性分析

摘要

Based on the Chaos Game Representation method(CGR) of DNA sequences and 4 Line Graphical Representation method(4-LGR) of DNA sequences,a novel graphical representation method of DNA sequences-Matrix Graphical Representation(MGR) is proposed. Based on the above three kinds of DNA sequences model,graphical representation of protein sequences is extended based on the detailed HP model respectively. The similarity of protein sequences is compared. The research shows that the method can illustrate the similarity of protein sequences,and is more flexible compared with the traditional method.%在DNA序列的混沌游走方法(CGR)及DNA序列的4线图谱表达方法(4-LGR)的基础上,提出了一种新型DNA序列的表达方法-矩阵图谱表达法(MGR),并进一步,在DNA序列的上述三种表达式基础上,分别推广建立了基于经典HP模型的蛋白质序列的图谱表达法,对蛋白质序列的相似性进行了比较验证.研究表明:矩阵图谱表达方法不仅能够说明蛋白质序列间的相似性,而且与传统的方法相比,该方法更具有灵活性和变通性.