基于结构模型的DBP-DNA识别及预测研究综述

摘要

DNA结合蛋白DBP(DNA Binding Protein)对细胞内遗传物质的生命活动中起着至关重要的作用,包括染色体的复制、剪切及基因表达调控.DBP通过与DNA发生结合反应,行使各种不同的生物功能.因此研究DBP-DNA之间的识别规律,对基因调控分析、蛋白功能预测和转录因子结合位点预测有着十分重要的意义.随着DBP-DNA复合物结构数据库的出现,基于结构信息的计算机分析方法为DBP与DNA之间的相互作用研究提供了新的发展契机.介绍了若干经典的DBP-DNA结构模型,简要评述了DBP-DNA结构分析方法目前的研究现状.%DNA Binding Protein ( DBP ) is of critica1 importance for life activities of intercellular genetic materials, including chromosome's replication, shearing and gene expression regulation. DBP executes different biological functions through generating binding reactions with DNA Therefore the researches on DBP-DNA' s recognition rule have great significance. for gene regulation annlysis, protein function prediction and transcription factor binding sites prediction. Along with the appearance of DBP- DNA complex structure database,computer analysing method based on structural information has provided a new development prospect on DBP-DNA interation researches.Here we reviewed a couple of classic DBP-DNA structual models and briefly commented the status quo of present DBP-DNA' structural analysis methods.