The Casimir effect of a piston for massless scalar fields which satisfy Dirichlet boundary conditions in the context of five-dimensional Randall-Sundrum models is studied. In these scenarios we derive and calculate the expression for the Casimir force on the piston. We also discuss the Casimir force in the limit that one outer plate is moved to the remote place to show that the nature of the reduced force between the parallel plates left. In the Randall-Sundrum model involving two branes the two plates attract each other when they locate very closely, but the reduced Casimir force turns to be repulsive as the plates separation is not extremely tiny, which is against the experimental phenomena, meaning that the RSI model can not be acceptable. In the ease of one brahe model the shape of the reduced Casimir force is similar to that of the standard two-parallel-system in the four-dimensional fiat spacetimes while the sign of force remains negative.
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