首页> 中文期刊> 《临床医学工程》 >浅部真菌病与病原菌菌种的临床分析

浅部真菌病与病原菌菌种的临床分析

             

摘要

Objective To analyze the species of superficial mycosis and the distribution characteristics of pathogenic bacteria strains. Methods 987 cases of patients with tentative diagnosis of superficial mycosis admitted to the dermatological department from December 2013 to June 2014 were selected as research objects. Microscopy, isolated culture and strain identification were used for clinical specimens. Results Of 987 samples, 280 cases (28.37%) were positive specimens with the method of microscopy, 190 cases (19.25%) with isolated culture and 316 cases (32.02%) with microscopy combined culture. The positive rate of combined test was higher than that of single microscopy and single culture, with statistically significant difference (P<0.05). 316 positive patients showed onychomycosis in 147 cases (46.52%), manus and tinea pedis in 72 cases (22.78%), tinea corporis in 64 cases (20.25%), tinea cruris in 29 cases (9.18%) and tinea capitis in 4 cases (1.27%). Onychomycosis and manus and tinea pedis were common in women, tinea corporis and tinea cruris were common in men, with statistically significant difference (P<0.05). Twelve kinds of pathogenic bacteria included 103 strains (32.59%) of trichophyton rubrum, 78 strains (24.68%) of candida, 67 strains (21.20%) of alpha fungus, 14 strains (4.43%) of aspergillus, 13 strains (4.11%) of dematiaceous fungi, 11 strains (3.48%) of rhodotorula, 7 strains (2.22%) of mucor, 6 strains (1.90%) of penicillium, 4 strains (1.27%) of microsporum canis, 2 strains (0.63%) of trichosporon, one strain (0.32%) of cryptococcus albidus and 10 strains (3.16%) of mixed infection. Conclusions The positive rate of microscopy combined culture is higher than that of single microscopy and single culture, onychomycosis and manus and tinea pedis are the most common superficial mycosis, and trichophyton rubrum and candida are the main pathogenic fungi.%目的:分析浅部真菌病种类和致病菌种分布特征。方法选取我院皮肤科2013年12月至2014年6月初步诊断为浅部真菌病的患者987例作为研究对象,取临床标本进行镜检、分离培养和菌种鉴定。结果987份送检标本中,镜检阳性标本280例(28.37豫),培养阳性标本190例(19.25豫),镜检结合培养阳性标本316例(32.02豫),镜检结合培养阳性率明显高于单一镜检阳性率和培养阳性率,差异具有统计学意义(P<0.05)。综合检测阳性的316例患者中甲癣147例(46.52豫),手足癣72例(22.78豫),体癣64例(20.25豫),股癣29例(9.18豫),头癣4例(1.27豫);其中甲癣和手足癣多发于女性人群,股癣和体癣多发于男性人群,差异具有统计学意义(P<0.05)。培养分离出的12种致病菌中红色毛癣菌103株(32.59豫),念珠菌属78株(24.68豫),须癣毛癣菌67株(21.20豫),曲霉菌属14株(4.43豫),暗色真菌属13株(4.11豫),红酵母菌11株(3.48豫),毛霉菌7株(2.22豫),青霉菌属6株(1.90豫),犬小孢子菌4株(1.27豫),毛孢子菌属2株(0.63豫),浅白隐球菌1株(0.32豫),混合感染10株(3.16豫)。结论培养结合镜检法的阳性率高于单一检查法,浅部真菌病以甲癣、手足癣较为多见,致病菌以红色毛癣菌和念珠菌属为主。

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