40例非霍奇金淋巴瘤患者VEGF与sCD40L的表达及临床意义

摘要

目的 探讨非霍奇金淋巴瘤(NHL) 血浆中血管内皮细胞生长因子(VEGF)与sCD40L表达、临床意义及相关性.方法 用ELISA检测40例NHL患者(NHL组)和10例健康志愿者(对照组)VEGF、sCD40L水平,以及NHL患者化疗后VEGF、sCD40L水平变化.分析NHL患者血浆中VEGF与sCD40L表达水平、临床意义和相关性.结果 化疗前NHL组患者VEGF表达水平高于对照组(P<0.001);而血浆sCD40L水平低于对照组(P<0.001),NHL化疗缓解组sCD40L在化疗后上升,与化疗前比较差异有统计学意义(P<0.001);VEGF化疗后下降,与化疗前比较差异有统计学意义(P<0.001);化疗前VEGF与sCD40L表达无相关性(P>0.05);sCD40L在首疗程化疗间歇期末达完全缓解(CR)组仍低于对照组(P<0.001);VEGF 在首疗程化疗间歇期末达CR组仍高于对照组(P<0.001).结论 VEGF、sCD40L可能与NHL的发病及预后有关,VEGF、sCD40L正常可作为NHL化疗停药的指征.%Objective To explore the expression and clinical significance of VEGF and sCD40L in plasma of non-Hodgkins lym-phoma(NHL) patients. Methods The expression of VEGF and sCD40L in plasma of 10 healthy persons and 40 NHL patients were detected by ELISA,The 40 NHL patients were divided into the before and after chemotherapy groups. Whose results were compared with eath other and those of 10 healthy persons. The relationship between VEGF and sCD40L in plasma of NHL patients was also analyed. Results The expression of VEGF in NHL patients was higher than that in the healthy matched controls(P＜0. 001) ; While the expression of SCD40L was lower than that of control group(P＜0. 001). The level of sCD40L expression was significantly increased after chemotherapy(P＜0. 001) ;The level of VEGF expression was significantly decreased(P＜0. 001). Before chemotherapy,There was no correlationship between the expression of VEGF and sCD40L in plasma of NHL patients(P＞0. 05). The expression of sCD40L in NHL patients who could not be CR in the intermittent period was lower than the control groups(P＜ 0. 001) ; However the expression of VEGF was still higher than the control groups(P＜0. 001). Conclusion VEGF and sCD40L may be related to the development and prognosis NHL patients,Therefore they may be considered the important indication of withdrawal in NHL patients.