叉头蛋白3在鼻咽非角化性鳞状细胞癌组织中的表达及意义

摘要

Objective To investigate the expression of FoxP3 in nasopharyngeal non-keratinizing squamous cell carcinoma and the significance of regulationary T (Treg) cell in the occurrence and development of nasopharyngeal carcinoma .Methods The im-munohistochemistry staining method(SP) was used to detect the expression of FoxP3 in 57 cases of nasopharyngeal non-keratiniz-ing squamous cell carcinoma and 22 cases of nasopharyngeal mucosa with chronic inflammation ,and the expression of CD8 in naso-pharyngeal carcinoma .Results The number of Treg cell with positive FoxP3 in the nasopharyngeal carcinoma group was 105 .05 ± 52 .22 ,which was significantly higher than 6 .35 ± 6 .06 in the nasopharyngeal mucosa with chronic inflammation ,the difference be-tween them showed statistical significance(P<0 .05) .The number of T cells with positive FoxP3 was relevant to gender and the differentiation degree of carcinoma(P<0 .05) .Conclusion The proliferation of Treg cells with positive FoxP3 can inhibit the anti-tumor immunologic function of the patients with nasopharyngeal non-keratinizing squamous cell carcinoma and provide the favor-able environment for the immunologic escape of tumor cells .%目的观察叉头蛋白3（FoxP3）在鼻咽非角化性鳞状细胞癌中的表达情况，以探讨调节性T（Treg）细胞在鼻咽癌发生、发展中的意义。方法通过免疫组织化学（S P ）法检测Fo x P3在57例鼻咽非角化鳞状细胞癌和22例鼻咽部黏膜慢性炎症中的表达情况及CD8在鼻咽癌中的表达。结果在鼻咽癌组中FoxP3阳性Treg细胞数（105．05±52．22）显著高于鼻咽部黏膜慢性炎症（6．35±6．06），二者的差异有统计学意义（P＜0．05）。FoxP3阳性Treg细胞的数量与患者性别及肿瘤分化程度有关（P＜0．05）。结论在鼻咽非角化鳞状细胞癌中，FoxP3阳性Treg细胞的增殖可能抑制机体的抗肿瘤免疫功能，并为肿瘤细胞的免疫逃逸提供良好的环境。