老年女性代谢综合征患者血尿酸水平及其与代谢组分的相关性分析

摘要

目的：探讨老年女性血尿酸（SUA）与代谢综合征（MS）及各代谢组分的相互关系。方法将147例年龄大于60岁的女性MS患者根据合并代谢组分的数量分为MSⅠ、Ⅱ、Ⅲ组，比较3组之间的SUA差异；采用四分位法将SUA分为4组，比较4组间代谢组分的差异。采用Logistic回归分析MS各代谢组分与SUA之间的相互关系。结果MSⅠ、Ⅱ组与MSⅢ组的SUA水平比较，差异有统计学意义（P＜0．05）；SUA4个区间q25（＜44．31mg/L）、q50（44．31～53．24mg/L）、q75（＞53．24～62．68mg/L）和q100（＞62．68mg/L）患者的腰围、收缩压（SBP）、舒张压（DBP）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）和空腹血糖（FPG）比较，差异均有统计学意义（P＜0．05）。与SUA＜44．31mg/L比较，SUA44．31～53．24、＞53．24～62．68、＞62．68mg/L3个区间的MS发生风险分别为1．87（95％CI1．35～2．59）、2．71（95％CI1．88～3．91）和4．88（95％CI3．12～7．63）。SUA的危险因素有腰围（OR＝2．56，95％CI1．52～4．31）、TG（OR＝2．21，95％CI1．63～3．00）、SBP（OR＝1．68，95％CI1．33～2．12）、DBP（OR＝1．84，95％CI1．41～2．40）、FPG（OR＝2．16，95％CI1．68～2．78）和代谢组分合并数量（OR＝2．87，95％CI1．89～4．36），SUA的保护因素有HDL-C（OR＝0．48，95％CI0．29～0．79）。结论SUA和MS各组分可能存在着相互作用。%Objective To discuss the relationship between serum uric acid (SUA) and the metabolic components in metabolic syndrome(MS) .Methods 147 female cases of MS aged >60 year old were divided into MS Ⅰ group ,MSⅡ group and MS Ⅲgroup according to numbers of metabolic components ,and the levels of SUA were compared among the three groups .These patients were also subdivided into 4 groups according to the SUA levels by the quartile division ,and the differences of the metabolic compo-nents were compared among the 4 groups .The relationship between SUA and various metabolic components of MS was analyzed by Logistic regression analysis .Results The SUA level had statistical difference among the MS Ⅰ group ,MSⅡ group and MS Ⅲgroup(P<0 .05);the four SUA intervals of q25(< 44 .31 mg/L) ,q50(44 .31 -53 .24 mg/L) ,q75(>53 .24 -62 .68 mg/L) and q100(>62 .68 mg/L) showed significant differences in waistline ,SBP ,DBP ,TG ,HDL-C and FPG(P<0 .05) .Compared with the SUA interval of <44 .31 mg/L ,the occurrence risk of MS in the SUA intervals of (44 .31-53 .24) ,> (53 .24-62 .68) and >62 .68 mg/L were 1 .87(95% CI1 .35-2 .59) ,2 .71(95% CI 1 .88 -3 .91) and 4 .88(95% CI 3 .12 -7 .63) ,respectively .Waistline(OR=2 .56 ,95% CI 1 .52-4 .31) ,TG(OR=2 .21 ,95% CI 1 .63-3 .00) ,SBP(OR=1 .68 ,95% CI 1 .33-2 .12) ,DBP(OR=1 .84 ,95% CI 1 .41-2 .40) ,FPG(OR=2 .16 ,95% CI 1 .68-2 .78) and numbers of metabolic components (OR=2 .87 ,95% CI 1 .89-4 .36) were the risk factors for SUA ,and the HDL-C was the protective factor(OR=0 .48 ,95% CI 0 .29-0 .79) .Conclusion There may be in-teraction between SUA and the metabolic components of MS .