超声弹性成像与磁共振对T1～2N1～2M0乳腺癌新辅助化疗疗效评估的对比研究

摘要

目的 探讨超声弹性成像与增强磁共振成像在T1～2 N1～2 M0乳腺癌新辅助化疗疗效评估中的应用价值.方法 收集2015年1月至2016年12月在重庆市肿瘤医院行乳腺癌手术并于术前行新辅助化疗患者23例.分别于第1次化疗前及手术前行乳腺起声弹性成像检查和增强磁共振成像检查.结果 以术后病理反应分级为基准,增强磁共振评价新辅助化疗疗效的灵敏度为94.1％,特异度为83.3％;弹性成像评价新辅助化疗疗效的灵敏度为88.2％,特异度为83.3％.与病理反应评价标准比较,两种检查方法诊断具有中等一致性(Kappa值分别为0.77、0.68).结论 超声弹性成像扩展了超声诊断依据,能够更全面地显示病变的性质,能有效反映新辅助化疗的效果.%Objective To investigate the application value of ultrasound elastography and contrast enhanced magnetic resonance imaging (CEMRI) in assessing the effect of neoadjuvant chemotherapy (NAC) for T1-2 N1-2 M0 breast cancer.Methods Twenty-three cases of breast cancer operation and receiving preoperative NAC in Chongqing Municipal Tumor Institute from January 2015 to December 2016 were collected.They all underwent ultrasound elastography and CEMRI before the first time NAC and operation respectively.Results Based on the postoperative pathological response grading,the sensitivity and specificity of CEMRI for evaluating the NAC effect were 94.1 ％ and 83.3％ respectively,which of ultrasound elastography were 88.2％ and 83.3％ respectively.The two kinds of examination method showed medium consistency(Kappa values were 0.77 and 0.68 respectively).Conclusion Ultrasound elastography extends the ultrasound diagnostic basis,can more comprehensively display the lesion character and more effectively reflect the NAC effect.