排钱草化学成分的研究

摘要

目的 研究排钱草Phyllodium pulchellum(L.)Desv.的化学成分.方法 排钱草95％乙醇提取物的乙酸乙酯和正丁醇部位采用Sephadex LH-20、硅胶、ODS、pre-HPLC等技术进行分离纯化,根据理化性质和波谱数据鉴定所得化合物的结构.结果 从中分离出11个化合物,分别鉴定为对羟基苯甲酸(1)、原儿茶酸(2)、原儿茶酸甲酯(3)、原儿茶酸乙酯(4)、没食子酸乙酯(5)、对香豆酸(6)、咖啡酸乙酯(7)、地芰普内酯(8)、尿苷(9)、熊果苷(10)、胡萝卜苷(11).结论 化合物4～11为首次从排钱草属植物中分离得到,化合物2、3为首次从该植物中分离得到.%AIM To study the chemical constituents from Phyllodium pulchellum (L.) Desv..METHODS The ethyl acetate and n-butanol fractions of P.pulchellum 95％ ethanol extract were isolated and purified by Sephadex LH-20,silica,ODS and pre-HPLC column,then the structures of isolated compounds were identified by physicochemical properties and spectral data.RESULTS Eleven compounds were isolated and identified as phydroxybenzoic acid (1),protocatechuic acid (2),protocaechuic acid methyl ester (3),protocatechuic acid ethyl ester (4),ethyl gallate (5),p-coumaric acid (6),caffeic acid ester (7),loliolide (8),uridine (9),arbutin (10),daucosterol (11).CONCLUSION Compounds 4-11 are isolated from genus Phyllodium for the first time,compounds 2 and 3 are first obtained from this plant.