去窦弓神经大鼠的胸主动脉重构

摘要

目的观察大鼠去窦弓神经（SAD）后由于血压不稳定而引起的血管重构。方法 10 wk大鼠行SAD或Sham，术后16周用离体动脉环实验测定SAD和相应Sham组大鼠胸主动脉对去甲肾上腺素（NE）和氯化乙酰胆碱（Ach）的收缩和舒张反应；用组织病理学和计算机图像分析技术对大鼠的胸主动脉连续切片进行观察和比较。结果与Sham组相比，SAD大鼠离体胸主动脉环对NE的收缩反应增强，对Ach的舒张反应减弱；SAD组大鼠胸主动脉的结构改变主要以血管中层平滑肌细胞肥大和基质扩充为主。结论大鼠去窦弓神经后单纯血压不稳定可引起血管重构。%AIM　To investigate the structural and functional remodeling of thoracic aortae in sinoaortic- denervated (SAD) rats. METHODS　SD rats underwent either SAD or sham-operation at the age of 10 weeks. Sixteen weeks after operation, the contraction and relaxation of the thoracic aortae were measured in isolated preparations; The morphological changes of arteries were examined by using histopathological method and computer image analysis. RESULTS　The NE-induced contraction was increased and Ach-induced relaxation of aortic rings was depressed in SAD rats; The structural remodeling of thoracic aortae was characterized by medial VSMC hypertrophy and matrix accumulations. CONCLUSION　Vascular functional and structural remodeling can be found in sinoaortic-denervated rats.