肥大细胞的酪氨酸激酶与抗过敏药物的分子靶向

摘要

The degranulation of mast cells represents a pivotal e-vent in the allergic disorders.The Src family kinases(SFKs)are as a starting signal in the activation of mast cell.Lyn,Fyn and Syk play important regulatory role in the degranulation of mast cells.Regulating SFKs can reduce the degranlation process and inhibit the allergic disorders.Therefore,SFKs inhibitors can be potential drugs in the allergy.It is necessary to study the targeted medicine of SFKs,which will be a new direction of drug develop-ment.%肥大细胞脱颗粒为过敏反应中的重要环节，其中 Src家族激酶（Src family kinase，SFKs）参与激活肥大细胞脱颗粒的起始信号。SFKs 中的 Lyn、Fyn、Syk 等在肥大细胞脱颗粒过程中发挥重要调节作用。调节 SFKs 可抑制肥大细胞脱颗粒过程，并抑制过敏反应的发生。因此，SFKs 抑制剂可以作为过敏性疾病的潜在药物。针对于 SFKs 的靶向药物的研发将是抗过敏药物发展的新方向之一。