流感病毒RNA聚合酶PA亚基：潜在抗流感药物靶点

摘要

Influenza is a globally serious contanious desease. The main problems faced with anti-influenza agents are the drug re-sistance and low efficacy to highly pathogenic virus. RNA poly-merase is acritical enzyme involved in replication and transcrip-tion of virus in the host cell, and the PA subunit, which provides primers for viral transcription via its endonuclease activity, is a promising anti-influenza target. This article mainly discusses the n PA subunit, including its structures, functions, and progress in the development of anti-influenza agents, providing information for research on the PA subunit and anti-influenza agents targeting PA subunit.%流感是世界范围内的严重传染性疾病，目前抗流感药物面临的主要问题是病毒耐药性和对高致病性流感病毒的效价低。流感病毒RNA聚合酶是病毒在宿主细胞内完成复制和转录过程的关键性酶，其中PA亚基通过内切酶活性为流感病毒的转录过程提供引物，成为潜在抗流感药物靶点。该文对PA亚基的结构、功能及内切酶抑制剂类抗流感药物研究进展进行概述，为PA亚基的深入研究及针对此靶点的抗流感药物发现提供信息指导。