源于植物内生无花果拟盘多毛抱真菌的新环氧环己二醇衍生物

摘要

AIM:To search for new cytotoxic secondary metabolites from solid cultures of the plant endophytic fungus Pestalotiopsis fici.METHOD:Pestalofones F-H(1-3)and pestalodiols A-D(4-7)were isolated from the crude extract using silica gel,Sephadex LH-20 column chromatography,and reversed-phase HPLC.Their structures were elucidated by NMR spectroscopy.The newmetabolites were tested for cytotoxicity against the HeLa and MCF-7 cells using the MTT method.RESULTS:Compounds 1-3 and 6showed cytotoxicity against HeLa and MCF-7 cells.CONCLUSION:Seven new cytotoxic isoprenylated epoxycyclohexanediol derivatives were identified from the plant endophytic fungus Pestalotiopsis fici.%从一株植物内生无花果拟盘多毛孢真菌的放大发酵产物中获得了7个新结构的异戊二烯取代环氧环己二醉衍生物,分别命名为pestalofones F-H(1-3)和pestalodiols A-D(4-7),并应用MS.NMR等光谱技术鉴定了其结构.化合物1-3,6和7对HeLa和MCF-7肿瘤细胞株具有中等程度的细胞毒活性.