妊娠期糖尿病患者牙周健康状况与血清应激反应指标的相关性分析

摘要

Objective To explore the relation between periodontal health conditions of gestational diabetes mellitus ( GDM) patients and serum stress reaction indexes.Methods Totally 85 woman with GDM hospitalized in treated in Hangzhou Traditional Chinese Medicine Hospital from February 2014 to February 2016 were selected in observation group, and 85 healthy pregnant woman taking routine check at the same time were selected in control group.Periodontal health situations, including gingival index ( GI) , bleeding on probing ( BOP) , attachment loss (AL), probing depth (PD), serum c-reactive protein (CRP), interleukin-2 (IL-2) and interleukin 8 (IL-8) of gingival sulcus fluid of two groups were compared.Results In the control group GI (t=5.32), BOP (χ2 =4.52), AL (t=5.24) and PD (t=4.65) were obviously better than those in the observation group ( all P <0.05 ) , and CRP, IL-2, IL-8 of the control group were significantly lower than those of the observation group (t value was 4.72, 5.21 and 4.77, respectively, all P<0.05).Serum CRP level, IL-2 and IL-8 of gingival sulcus liquid were obviously and positively correlated with blood sugar levels in different groups ( r value was 0.31, 0.45 and 0.39, respectively, all P<0.05).Conclusion Serum stress reaction indexes of patients with GDM are relatively high, which is correlated with periodontal health conditions in pregnancy.%目的 对妊娠期糖尿病患者牙周健康状况与血清应激反应指标进行相关性分析.方法 选取杭州市中医院自2014年2月至2016年2月期间收治的85例妊娠期糖尿病孕妇作为观察组,另选择同时期来院行常规体检的正常孕妇85例为对照组,对比两组研究对象的牙周健康状况,包括牙龈指数(GI)、探诊出血(BOP)阳性位点率、附着丧失水平(AL)、牙周袋探诊深度(PD),以及两组研究对象血清C-反应蛋白(CRP)、龈沟液白细胞介素-2(IL-2)、白细胞介素-8(IL-8)水平.结果 对照组孕妇GI(t=5.32,P<0.05)、BOP阳性位点率(χ2=4.52,P<0.05)、AL(t=5.24,P<0.05)及PD(t=4.65,P<0.05)等牙周健康指数均显著优于观察组孕妇,且对照组孕妇血清CRP水平和龈沟液IL-2、IL-8水平均显著低于观察组孕妇(t值分别为4.72、5.21、4.77,均P<0.05).不同组别孕妇血清CRP水平、龈沟液IL-2、IL-8水平与其血糖水平具有明显的正相关关系(r值分别为0.31、0.45、0.39,均P<0.05).结论 妊娠期糖尿病血清应激反应指标水平较高,与妊娠期牙周健康有一定关系.