新生儿糖尿病并发颅内出血1例报告及文献复习

摘要

Objective To explore the diagnosis and treatment of neonatal diabetes mellitus (NDM) and the pathogenesis of it complicating intracranial hemorrhage .Methods Clinical data of a case of NDM complicating intracranial hemorrhage was analyzed and related literatures were reviewed.Results KCNJ11 and ABCC8 gene mutation associated NDM accounted for about 40% of all NDM, and it accounted for 50%of permanent neonatal diabetes mellitus ( PNDM ) . There could be connection between NDM and intracranial hemorrhage . Conclusion Older neonates with diabetes mellitus can use glibenclamide for trial treatment .Intracranial hemorrhage may be exudative hemorrhage, which could be related with ATP sensitive potassium channel ( KATP) lesion distributed in neurons and blood vessels in brain.%目的：探讨新生儿糖尿病的诊治及其并发颅内出血的发病机制。方法分析1例新生儿糖尿病并发颅内出血的临床资料及复习相关文献。结果 KCNJ11及ABCC8基因突变相关性新生儿糖尿病患儿约占所有新生儿糖尿病（ NDM）患儿的40％，占新生儿永久性糖尿病患儿（ PNDM）的50％；新生儿糖尿病与颅内出血可能存在联系。结论较长新生儿糖尿病患儿可试验性应用格列本脲治疗；并认为颅内出血可能为渗出性出血，可能与分布于脑部神经元、血管内的ATP敏感钾通道（ KATP）病变有关。