Objective To analyze the curative effect of spleen ammonia peptide oral freeze-dried power on treatment of children pneumonia mycoplasma infection and its influence on immunological indexes .Methods From July 2012 to July 2014 100 cases of pneumonia mycoplasma infection admitted in Longquan People ’ s Hospital were selected as research objects , and they were divided into convention group and spleen ammonia peptide group according to random number table method with 50 cases.The convention group was given fundamental anti-infection and anti -viral treatment , while the spleen ammonia peptide group was provided with spleen peptide oral ammonia based on foundation treatment .The clinical curative effect , symptoms disappear ance time , incidence of respiratory tract infection and immunological indexes changes were compared between two groups .Results In spleen ammonia peptide group , the total effective rate increased but incidence of respiratory tract infection decreased obviously compared with the conventional group (χ2 value was 4.35 and 4.45, respectively, both P<0.05).The symptoms disappear ance time was significantly shorter in spleen ammoniac peptide group than that in the conventional group (t =2.89, P <0.05).In the conventional group, IgM, IgA and C4 levels after treatment increased significantly than those before treatment (t value was 2.34, 3.11 and 3.45, respectively, all P<0.05).In Spleen ammonia peptide group, IgM, IgA and C4 levels after treatment were more significantly higher than before treatment ( t value was 2.93, 3.67 and 4.03, respectively, all P<0.05).After treatment, IgM, IgA and C4 level in spleen ammonia peptide group increased more obviously than in the conventional group (t value was 3.25, 3.43 and 3.56, respectively, all P<0.05).Conclusion Foundation treatment combined with spleen ammonia peptide oral freeze -dried powder for treatment of children pneumonia mycoplasma infection is worthy of popularization and application for significant clinical efficacy , improving of immunological indexes and enhancing body resistance .%目的：分析脾氨肽口服冻干粉治疗小儿肺炎支原体感染的疗效及对免疫学指标的影响。方法选取龙泉市人民医院自2012年7月至2014年7月收治的100例肺炎支原体感染患儿作为研究对象，采取随机数字表法分为常规组与脾氨肽组，每组各50例，常规组给予抗感染、抗病毒等基础治疗，脾氨肽组在其基础上加用脾氨肽口服冻干粉治疗，对比两组患儿临床疗效、症状消失时间、呼吸道感染发生率及免疫学指标变化情况。结果脾氨肽组较常规组相比总有效率明显升高，呼吸道感染发生率明显降低，差异均具有统计学意义（χ2值分别为4．35、4．45，均P＜0．05）。脾氨肽组较常规组的症状消失时间明显缩短，差异具有统计学意义（t＝2．89，P＜0．05）。常规组治疗后较治疗前的免疫球蛋白（Ig）M、IgA及补体C4水平均明显升高，差异均具有统计学意义（t值分别为2．34、3．11、3．45，均P＜0．05）。脾氨肽组治疗后较治疗前的IgM、IgA及C4水平均明显升高，差异均具有统计学意义（t值分别为2．93、3．67、4．03，均P＜0．05）。脾氨肽组治疗后较常规组治疗后的IgM、IgA及C4水平均更加明显（t值分别为3．25、3．43、3．56，均P＜0．05）。结论于常规治疗基础上加用脾氨肽口服冻干粉可获得显著临床疗效，改善了免疫学指标，提高了机体抵抗力，值得推广与应用。
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