目的 研究妊娠早期血浆甘油三酯与妊娠期并发症及妊娠结局之间的关系.方法 收集2014年4至11月在张家港市妇幼保健所首次建卡的孕妇资料共442名,均为妊娠满11周不满14周的单胎孕妇,根据血浆甘油三酯的水平分为观察组和对照组.跟踪监测并记录妊娠期并发症及妊娠结局,分析观察组和对照组之间妊娠期并发症及妊娠结局之间的差异.结果 在年龄>20～30岁的妊娠女性中,体重和体质指数(BMI)可以显著影响妊娠早期孕妇体内甘油三酯水平,在观察组中总妊娠期并发症 、妊娠期糖尿病 、妊娠期高血压的相对危险度明显高于对照组(χ2=4.461,OR=1.929;χ2=3.968,OR=2.047;χ2=7.870,OR=3.524,均P<0.05);而在年龄>30岁的妊娠女性中,仅BMI可以影响妊娠早期孕妇体内甘油三酯水平,在观察组中仅总妊娠期并发症的相对危险度高于对照组(χ2=4.494,OR=2.348,P<0.05).新生儿体重:观察组(3473.151±321.800)g高于对照组(3378.809±399.020)g,差异具有统计学意义(t=2.135,P=0.035).妊娠早期血浆甘油三酯水平与血糖(r=0.133,P=0.005)、总胆固醇(r=0.330,P=0.000)及同型半胱氨酸(r=0.120,P=0.012)之间显著相关.结论 妊娠早期血浆甘油三酯水平升高与妊娠期并发症及不良妊娠结局相关.妊娠早期开始监测血浆甘油三酯水平并及时干预,有助于降低妊娠期并发症及不良妊娠结局的发生.%Objective To investigate the relationship among triglyceride level in early pregnancy , pregnancy complications and pregnancy outcomes .Methods From April to November in 2014442 singleton women being pregnant for 11 - 14 weeks were included in this study .They all set up health card for the first time in Zhangjiagang Maternal and Child Health Care Hospital . According to serum triglyceride level the cases were divided into experimental group and control group .Serum triglyceride levels were monitored and pregnancy complications as well as pregnancy outcomes were recorded .The differences in pregnancy complications and pregnancy outcomes between two groups were analyzed .Results Among pregnant women aging twenty to thirty , height and body mass index (BMI) could significantly affect triglyceride level in early pregnancy .Relative risk degree of total pregnancy complications ,gestational diabetes mellitus and hypertensive disorder complicating pregnancy was significantly higher in experimental group (χ2 = 4 .461 ,OR = 1 .929 ;χ2 = 3 .968 ,OR = 2 .047 ;χ2 = 7 .870 ,OR = 3 .524 ,all P < 0 .05) .Among pregnant women over 30 years ,only BMI could affect the level of triglyceride in early pregnancy ,and only relative risk of pregnancy complications was higher in experimental group (χ2 = 4 .494 ,OR = 2 .348 , P < 0 .05) .Neonatal weight in experimental group was higher than in control group (3473 .151 ± 321 .800g vs 3378 .809 ± 399 .020g) with statistical significance (t = 2 .135 , P = 0 .035) . Triglyceride level in early pregnancy was positively correlated with blood glucose (r = 0 .133 , P = 0 .005) ,total cholesterol (r =0 .330 ,P = 0 .000) and homocysteine (r = 0 .120 , P = 0 .012) .Conclusion The increased level of triglyceride in early pregnancy is correlated with pregnancy complications and adverse pregnancy outcomes .Detecting serum triglyceride level at early pregnancy and timely prevention will reduce the incidence of pregnancy complications and adverse pregnancy outcomes .
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