Objective To investigate the expression of breast cancer anti-estrogen resistance 1(BCAR1)in ectopic endometrium and eutopic endometrium in patients with endometriosis(EMS)and to analyze its clinical significance.Methods 100 EMS patients treated in Yueqing Municipal People's Hospital of Zhejiang Province from February to December in 2016 were selected as subjects, and healthy adults who underwent physical examination in the hospital were selected as controls.Expression of BCAR1 and levels of vascular endothelial growth factor(VEGF),tumor necrosis factor alpha(TNF-α),interleukin-1β(IL-1β),and cancer antigen 125(CA125)were observed in two groups.BCAR1was compared between ectopic endometrium and eutopic endometrial in EMS patients,and analysis was conducted on correlation of BCAR1 expression in patients with EMS and levels of VEGF,TNF-α,IL-1β and CA125.Results Positive expression rate of BCAR1 in eutopic endometrium of EMS group was 85.00%,which was significantly higher than that of the control group(χ2=106.676,P<0.001).Levels of serum VEGF,TNF-α,IL-1β and CA125 in EMS group of patients were 228.72 ± 12.35ng/L,46.33 ± 5.96Pg/ml,165.82 ± 13.02ng/L,332.46 ± 12.13U/ml,respectively,which were significantly higher than those in the control group(t value was-39.764,-41.339,-24.083 and-97.792,respectively,all P<0.001).Positive expression rate of BCAR1 was 95.0% in EMS patients with ectopic endometrium,and it was significantly higher than that in eutopic endometrium(χ2= 15.686,P < 0.001).A significant positive correlation was found between positive expression rate of BCAR1 and serum levels of VEGF,TNF-α,IL-1β and CA125(r value was 0.587,0.612,0.542 and 0.598, respectively,all P<0.05).Conclusion Positive expression rate of BCAR1 in ectopic endometrium of EMS patients is relatively high,and it is positively corralted with the serum levels of VEGF,TNF-α,IL-1β and CA125.So it can be used as an important index for clinical monitoring.%目的 观察子宫内膜异位症(EMS)患者异位和在位内膜组织中抗雌激素药物耐药性基因1(BCAR1)表达,并分析其临床意义.方法 选取2016年2月至2016年12月在浙江省乐清市人民医院接受治疗的100例EMS患者为研究对象(EMS组),同时选取同期在浙江省乐清市人民医院接受体检筛查的100例健康成年人作为对照组.观察两组内膜组织中BCAR1的表达和血管内皮生长因子(VEGF)、肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、癌抗原125(CA125)水平,比较EMS患者异位内膜及在位内膜组织中BCAR1的差异,分析子宫内膜异位症患者BCAR1表达与VEGF、TNF-α、IL-1β、CA125水平的相关性.结果 EMS组患者组织中的BCAR1阳性表达率为85.00%,明显高于对照组(χ2=106.676,P<0.001);EMS组患者血清VEGF、TNF-α、IL-1β、CA125水平分别为228.72±12.35ng/L、46.33±5.96pg/mL、165.82±13.02ng/L、332.46±12.13U/mL,明显高于对照组(t值分别为-39.764、-41.339、-24.083、-97.792,均P<0.001);EMS患者异位内膜中BCAR1阳性表达率为95.0%,明显高于在位内膜中BCAR1阳性表达率(χ2=15.686,P<0.001);子宫内膜异位症患者BCAR1阳性表达率与血清VEGF、TNF-α、IL-1β、CA125水平明显正相关(r值分别为0.587、0.612、0.542、0.598,均P<0.05).结论 EMS患者的异位内膜组织中BCAR1阳性表达率较高,且与患者血清VEGF、TNF-α、IL-1β、CA125水平正相关,可作为临床监测的重要指标.
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