间隔缺损性先天性心脏病胎儿脐动脉及大脑中动脉搏动指数的变化

摘要

Objective To evaluate the significance of change in umbilical artery(UA)and middle cerebral artery (MCA)pulsatility index(PI)in fetuses with congenital heart disease(CHD)of septal defect. Methods Umbilical artery (UA)and middle cerebral artery(MCA) pulsatility index(PI) were retrospectively analyzed in 82 fetuses with CHD, including 25 cases of atrioventricular septal defect(AVSD) ,51 cases of ventricular septal defect(VSD)and 6 cases of atrial septal defect(ASD). The control group comprised 660 healthy fetuses of uncomplicated pregnancies matched for gestational age. Individual PI measurements were converted into Z-scores for statistical analysis. Results Fetuses with AVSD、VSD and all CHD had an increased UA-PI compared to the controls respectively(P＜0. 05), but no difference was observed in UA-PI between fetuses with ASD and the controls(P＞0. 05). There was no significant difference in MCA-PI between fetuses with AVSD,VSD,ASD,all CHD and the controls(P＞0. 05). Conclusions UA-PI in fetuses with AVSD and VSD may increase,however, MCA-PI does not change remarkably.%目的 探讨几种间隔缺损性的先天性心脏病胎儿的脐动脉搏动指数(UA-PI)、大脑中动脉搏动指数(MCA-PI)的变化.方法 回顾性分析82例间隔缺损性的先天性心脏病胎儿(疾病组)的脐动脉(UA)和大脑中动脉(MCA)的搏动指数(PI),其中包括25例房室隔缺损(又称心内膜垫缺损,AVSD组)、51例室间隔缺损(VSD组),6例房间隔缺损(ASD组);另随机选择660例按孕龄分组的正常的胎儿作为正常对照组.对所有PI值进行标准正态转换后再进行统计分析.结果 疾病组AVSD组,VSD组胎儿的UA-PI均比正常对照组胎儿高(P＜0.05),而ASD组胎儿与正常对照组胎儿的UA-PI无明显差别(P＞0.05);疾病组AVSD组、VSD组、ASD组胎儿与正常对照组胎儿的MCA-PI均无明显差别(P＞0.05).结论 AVSD、VSD的胎儿在官内可能会出现UA-PI增高,而MCA-PI无明显改变.