目的 探讨Cool-tip冷循环射频消融系统治疗大肠癌肝转移,用统计学方法分析影响其生存期的预后因素.方法 对46例(共125个肝内转移灶)大肠癌患者进行射频消融治疗,观察治疗后患者的复发和生存情况.采用Kaplan-Meier模型和Log rank检验进行单因素分析,采用COX比例风险模型进行多因素分析,分析患者可能的预后影响因素.结果 分析可能影响生存期的21项单因素中,3项有统计学意义,分别为:肝功能Child-Pugh分级、初次RFA前癌胚抗原(CEA)值、治疗目的方案.与生存期相关的多因素有2项,分别为:肝功能Child-Pugh分级、治疗目的方案.结论 超声引导下RFA治疗肝转移癌,影响治疗预后的因素为:肝功能Child-Pugh分级、初次RFA前癌胚抗原(CEA)值、治疗目的方案.此结果有助于指导RFA治疗.%Objective To investigate the prognostic factors affecting outcome in Radiofrequency ablation( RFA) of colorectal liver metastases(CRLM) by statistics analyses. Methods We retrospectively reviewed 46 colorectal liver metastases patients with 125 lesions underwent RFA. We recorded and analyzed potential prognostic factors. Kaplan-Meier model and log-rank test were used in univariate analyses and COX regression model was used in multivariate analyses. Results On the univariate analysis, overall survival were significantly improved in 3 factors: carcinoembryonic antigen (CEA)≤100 ng/ml, Child-Pugh grade, treatment purpose and method. On the multivariate analysis, significant survival factors were Child-Pugh grade, treatment purpose and method. Conclusions RFA for colorectal liver metastases is an effective treatment option in patients with Child-Pugh grade A, and in patients with CEA≤100 ng/ ml, while treatment purpose and method also had significant action on survival.
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