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肺透明细胞瘤七例临床特点

摘要

目的 探讨肺透明细胞瘤的临床、影像、病理特征及诊断和治疗要点,提高临床医生的诊治水平.方法 同顾分析苏州大学附属第一医院2000年1月至2010年12月收治的7例肺透明细胞瘤患者的临床资料,总结其临床特点,为肺透明细胞瘤的诊治提供借鉴和帮助.结果 7例中男3例,女4例,年龄25 ~ 76岁,平均(55±16)岁.肿瘤均呈单发圆形钱币状结节,最大直径平均为(2.4±0.7)cm,病变位于右上叶、中叶各1例,左上叶2例,左下叶3例.所有病例均行手术切除并经病理确诊,肿瘤标本PAS染色阳性,免疫组织化学染色显示黑色素生成及肌源性标志物阳性,而上皮源性标志物阴性.7例患者随访均未见复发.结论 肺透明细胞瘤是罕见的肺部良性肿瘤,具有独特的临床、影像及病理特点,确诊有赖于常规病理及免疫组织化学染色;确诊后应尽早手术并长期随访.%Objective To study the clinical characteristics,chest imaging,pathology,diagnosis and treatment of clear cell tumor of the lung ( CCTL). Methods Seven cases of CCTL diagnosed from January 2000 to December 2010 in our hospital,and 38 cases from literaturcs published in mainland of China,were retrospectively analyzed.Results The age of the patients was (55 ± 16) years,with equal sex distribution. In most of the patients,the lesions were incidentally found during routine examinations. Chest roentgenogram or CT scan showed a homogenous,rounded opacity (solitary nodule) of (2.4 ± 0.7) cm in diameter.Contrast-enhanced CT scans revealed a sign of intense enhancement because of these tumors were highly vascular,containing capillaries and sinusoidal vessels in some patients. Pathologic examination showed rounded and oval tumor cells with abundant clear cytoplasm,distinct cell borders,and cytoplasm rich in periodic acid Schiff-positive glycogen granules.Immunohistochemically,CCTL expressed melanocytic and myogenic markers, such as human melanoma black-45 (HMB-45), HMSA-1 and actin. But its epithelial markers were negative. Resection via operation was the only effective method till now.Conclusions CCTL is a rare benign tumor with special features of clinical characteristics,radiology and pathology.The diagnosis is based on distinct pathologic characteristics. Earlier operation with long term follow-up is recommended.

著录项

  • 来源
    《中华结核和呼吸杂志》|2012年第9期|679-682|共4页
  • 作者单位

    215006 苏州大学附属第一医院呼吸内科;

    215006 苏州大学附属第一医院病理科;

    215006 苏州大学附属第一医院呼吸内科;

    215006 苏州大学附属第一医院呼吸内科;

    215006 苏州大学附属第一医院呼吸内科;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类
  • 关键词

    肺肿瘤; 透明细胞瘤;

  • 入库时间 2023-07-25 11:41:23

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