甲壳素及其衍生物抑制瘢痕形成：研究与进展

摘要

背景：甲壳素及其衍生物抑制瘢痕形成方面的作用及机制成为近年来研究的热点。　　目的：综述就近年来甲壳素及其衍生物抑制瘢痕形成的研究进展。　　方法：应用计算机检索中国知网、万方数据库、维普数据库及PubMed数据库，检索有关甲壳素抑制瘢痕治疗进展的文献，检索中文关键词为“甲壳素，衍生物，瘢痕形成”，英文关键词为“Chitin； Derivatives； Scar Formation”。　　结果与结论：甲壳素及其衍生物能直接或通过改变如生化因子、干扰素、肿瘤坏死因子、白细胞介素等各种因子，抑制瘢痕中成纤维细胞的增殖、分化及分泌功能；能改变伤口及瘢痕中免疫细胞的作用；能减少胶原形成，促进胶原降解；促进伤口肉芽血液循环的建立，减轻组织缺氧；促进表皮细胞和内皮细胞的生长，加速伤口愈合；抑制创面细菌繁殖，减轻感染，加速愈合。%BACKGROUND:In recent years, chitin and its derivatives have become a hotspot because of their action and mechanism of inhibiting scar formation. OBJECTIVE: To review the research progress in chitin and its derivatives that inhibit scar formation. METHODS:A computer-based search of CNKI, Wanfang, VIP and PubMed databases was performed for articles related to inhibitory effect of chitin on scar formation. The keywords were “chitin; derivatives; scar formation” in Chinese and English, respectively. RESULTS AND CONCLUSION:Chitin and its derivatives can inhibit fibroblast proliferation, differentiation and secretion in the scar directly or through altering different factors, such as biochemical factors, interferons, tumor necrosis factor, and interleukin; alter the role of immune cels in the wound and scar; reduce colagen formation and promote colagen degradation; promote the establishment of wound granulation blood circulation, thereby reducing tissue hypoxia; facilitate the growth of epidermal cels and endothelial cels to accelerate wound healing; inhibit wound bacteria, reduce wound infections and accelerate wound healing.