Objective We aimed to elucidate the relationship between mild to moderate renal impaire-ments and burden of atherosclerosis in patients with acute coronary syndrome ( ACS ) .Methods A total of 150 patients with ACS were included in the study .Gensini and SYNTAX scores were also calculated .Kidney function was classified based on estimated glomerular filtration rate ( eGFR) into stage 1:eGFR>90,stage 2:60 to 89,and stage 3:30 to 60 ml/min/1.73 m2 .Results Gensini and SYNTAX scores were higher in stages 2 and 3 than in stage 1.Also,the number of diseased vessels ,number of critical lesions (>50%and 70%),left main disease ,and number of total occlusion vessels were higher in stages 2 and 3 than in stage 1.Multivariate linear regression analysis demonstrated that a decreased eGFR was an independent risk factor for SYNTAX and Gensini scores together with age and male gender .Conclusion Mild to moderate kidney dysfunction was inde-pendently associated with the burden of atherosclerosis after adjustment for traditional CV risk factors.%目的：探讨轻中度肾功能不全和急性冠脉综合征（ ACS）患者冠脉粥样硬化负担间的关系。方法连续性入选于2012年3月至2013年12月就诊于我院的150例ACS患者。研究计算了患者的Gensini和SYNTAX评分。根据估算肾小球滤过率（ eGFR）将患者分为三期：一期为eGFR＞90；2期为60～89；3期为30～60 ml/min/1．73 m2。比较不同分类间患者的临床特征及冠脉粥样硬化负荷情况。结果第2期和第3期患者的Gensini和SYNTAX分数比第一期高。同样，第2期和第3期患者中，冠脉病变的数量、严重病变血管的数量（＞50％和70％）、左主干病变和完全闭塞的血管数量比第1期患者更高。多元线性回归分析表明eGFR降低以及年龄和男性是Gensini和SYNTAX分数的独立危险因素。结论在校正传统的心血管危险因素后，轻中度肾功能不全与动脉粥样硬化负担独立相关。
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