新型含氨基酸官能团的香豆素衍生物的合成

摘要

Corresponding methyl ester hydrochloride (2a ~2d) were prepared from L-phenylalanine (1a), L-tryptophan(1b), L-tyrosine(1c) and histidine (1d) in Me3 SiCl-MeOH(Ⅲ) system.7-(Menthoxyacetic acid) coumarin(6) was prepared by a two-step reaction from 7-hydroxycoumarin.A novel coumarin derivative , N-acetylcoumarin ( oxygen-7-coumarin )-3-phenyl-2-amino-methyl propio-nate, was synthesized by acylation reaction of 6 with 3a.The structure was characterized by 1 H NMR, 13 C NMR and FT-IR.%以L-苯丙氨酸、L-色氨酸、L-酪氨酸和组氨酸为原料,在Me3 SiCl-MeOH(Ⅲ)体系中反应合成了相应的甲酯盐酸盐(2a~2d);以7-羟基香豆素为原料,经两步反应制得7-(乙酸氧基)香豆素(6);6与3a经酰胺化反应合成了一种新型的香豆素衍生物——N-乙酰基-(氧-7-香豆素)-3-苯基-2-氨基-丙酸甲酯,其结构经1 H NMR,13 C NMR和FT-IR表征.