小肠黏膜相关淋巴组织淋巴瘤临床病理特征与预后因素

摘要

Objective To explore the relationship between the clinicopathological characteristics and prognosis of mucosa-associated lymphoid tissue lymphoma in small intestine.Methods The clinicopathological data of 16 cases of mucosa-associated lymphoid tissue lymphoma in small intestine were studied retrospectively.Results Among the 16 patients with follow-up for more than two years, the 2-yer survival rate was significantly higher in patients of B-cell lymphoma than those with T-cell lymphoma (P ＜ 0.01), and it was significantly higher in patients of stage IE/IIE than those of stage ⅢE (P ＜ 0.05) while that was significantly higher in patients with chemotherapy after surgery than those without chemotherapy after surgery (P＜ 0.05).Conclusion The clinical stage and histological finding are important prognostic factors for mucosa-associated lymphoid tissue lymphoma in small inestine.Radical resection is the key factor in improving the prognosis of mucosa-associated lymphoid tissue lymphoma in small intestine patients.Chemotherapy and surgery are useful adjuvant treatments.%目的:探讨小肠黏膜相关淋巴组织淋巴瘤的临床病理特征与预后的关系.方法:对16例小肠黏膜相关淋巴组织淋巴瘤患者的临床病理资料进行回顾性分析.结果:16例均经过2年以上的随访,B细胞型淋巴瘤患者的2年生存率显著高于T细胞型淋巴瘤患者(P＜0.01),ⅠE/ⅡE期的2年生存率显著高于ⅢE期(P＜0.05),手术联合术后化疗者的2年生存率显著高于单纯手术者(P＜0.05).结论:免疫分型和分期是预后的主要指标,手术和术后化疗是治疗小肠黏膜相关淋巴组织淋巴瘤的重要手段.