涎腺多形性腺瘤中Gli-2蛋白的表达及意义

摘要

Objective To examine the expression of hedgehog signaling pathway zinc finger transcription factor Gli-2 protein in salivary pleomorphic adenoma.Methods The expression of Gli-2 protein in 60 cases of salivary pleomorphic adenoma was detected by immunohistochemistry.Results High expression of Gli-2 protein in pleomorphic adenoma was detected in the nucleus.The expression of Gli2 was strongly positive in 21 cases ( 35％ ),positive in 27 cases ( 45％ ),weakly positive in 6 cases ( 10％ ) and negative in 6 cases( 10％ ).The positive rate of Gli-2 expression was 90％ and the expression strength was 89％.Conclusions The Gli-2 protein in pleomorphic adenoma was up-regulated.The abnormal activation of the pathway may take part in the tumorigenesis of salivary pleomorphic adenoma.%目的 探讨转录因子Gli-2蛋白在涎腺多形性腺瘤(salivary pleomorphic adenoma,SPA)组织中的表达及其生物学意义.方法 采用免疫组织化学方法检测60例SPA组织中Gli-2蛋白的表达情况并进行分析.结果 Gli-2蛋白在60例SPA组织中高表达,主要表达在细胞核内,呈棕黄色颗粒.21例(35％)呈强阳性(+++),27例(45％)较强阳性(++),6例(10％)弱阳性(+),6例(10％)阴性(-).Gli-2蛋白在SPA中的表达阳性率达90％( 54/60),表达强度达89％ (53/60).结论 Gli-2蛋白在SPA组织中呈高表达状态,其所引起的Hedgehog信号通路的过度激活可能参与了SPA的发生和发展.