目的 评价两种市售去渍美白类牙膏去除牙齿外源性色素的临床效果.方法 研究对象共148名,均为男性吸烟者,年龄19 ～ 60岁.采用随机、双盲、三单位平行设计,根据Lobene色斑指数(包括染色面积及程度)均数将受试者平衡地分为3组,分别使用试验牙膏A(A组):含3％聚乙二醇-400和2％氧化铝；牙膏B(B组):含2.5％聚乙二醇400和0.5％焦磷酸四钠；对照牙膏C(C组):市售无去渍美白功效牙膏,分别于基线、第4、8周由同一名检查者完成所有研究对象的色斑指数测定.结果 共有121名受试者完成了8周的临床研究.基线检查3组的色斑指数差异无统计学意义(P＞0.05),试验4周后,与C组(2.24)相比,A、B组受试者的色斑面积指数(A组:2.05,B组:2.08)分别降低了8.48％和7.14％ (P ＜0.05),色斑程度指数(A组:1.79,B组:1.81)与C组(1.89)相比分别降低了5.29％和4.23％ (P ＜0.05).8周后,相比C组(2.09),A、B组的色斑面积指数(A组:1.77,B组:1.78)分别降低了15.31％和14.83％ (P ＜0.05),色斑程度指数(A组:1.45,B组:1.43)与C组(1.66)相比分别降低了12.65％和13.86％ (P ＜0.05).结论 试验观察期内,日常使用脱渍牙膏对吸烟人群因吸烟导致的牙齿表面烟渍和外源性色素有一定去除作用.%Objective To investigate the extrinsic stain removal efficacy of two commerciallyavailable dentifrices (LION (R) ZACT(R) ).Methods After informed consent was assigned,148 male smokers,aged 19-60 yeas,were recruited in this study.In this double blind,randomized,parallel study,three groups were balanced according to Lobene stain index ( including area and intensity) at baseline and then randomly assigned into three treatment groups:Toothpaste A containing 2％ alumina or Toothpaste B containing 0.5％ four sodium pyrophosphate,Toothpaste C:control dentifrice.Stain level was assessed by one qualified examiner at baseline,4 weeks and 8 weeks after baseline.Results After 4-week use of the assigned dentifrices,the groups using Toothpaste A and B demonstrated significant stain area reduction of 8.48％ and 7.14％,with stain intensity reduction of 5.29％ and 4.23％ compared with the control group ( P ＜ 0.05 ).After 8-week use of Toothpaste A and B,the two groups demonstrated a significant ( P ＜ 0.01 ) stain area reduction of 15.31％ and 14.83％,with stain intensity reduction of 12.65％ and 13.86％,as compared to the control group.Conclusions The dentifrices containing 2％ alumina or 0.5％ four sodium pyrophosphate are effective for the removal of extrinsic tooth stain after four weeks,and eight weeks of use.
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