目的 探讨生长抑素联合长期全肠外营养(TPN)在胃肠道肿瘤所致恶性肠梗阻治疗中的作用.方法 将2003年1月至2008年6月的29例胃肠道恶性肿瘤所致恶性肠梗阻患者随机分为对照组(单独TPN治疗)11例、治疗组(生长抑素联合TPN治疗,其中奥曲肽100 μg皮下注射,3次/d,用药2周)18例,比较两组治疗前后的疗效差异.结果 治疗组临床症状较对照组明显改善,腹痛、腹胀缓解率分别为83.33%、45.45%;肛门排气比例分别为66.67%、27.27%;治疗组胃肠减压量比对照组减少尤为显著;生活质量明显改善,治疗组治疗后其生存质量评分(KPS)分值88.89%的患者高于60分.结论 在恶性肠梗阻患者中,常规TPN治疗时联合应用生长抑素,能够明显改善患者的临床症状和生活质量.%Objective To investigate the effects of somatostatin combined with total parenteral nutrition(TPN) on malignant bowel obstruction(MBO) due to inoperable gastrointestiinal carcinoma. Methods From Jan. 2003 to Jun. 2008, 29 patients with MBO due inoperable gastrointestinal carcinoma were randomly divided into two groups:the control group(only TPN group) 11 cases and the treatment group(somatostatin combined with TPN) 18 cases(octreotide, 100 μg, subcutaneous injection, tid, for two weeks). The effects were compared between the two groups. Resuits After the treatment, the clinical symptoms of abdominal distention and abdominal pain were relieved significantly (83.33% to 45.45%), the echaust of anus was 66.67% to 27.27%. The average volume of gastroenteral decom-pression reduced more efficiently. Qaality of life, evaluated with Karnofsky score, was improved significantly, the KPS of 88.9% treatment group were higher than 60. Conclusions The administration of somatostatin combined with TPN is effective in the MBO due to inoperable gastrointestinal carcinoma. It can obviously relieve the symptoms of MBO and improve the quality of life in patients.
展开▼
