基于NF-κB信号通路的咖啡酸苯乙酯抗炎和抗肿瘤作用研究进展

摘要

咖啡酸苯乙酯(CAPE)是源于蜂胶的小分子化合物,具有抗炎、免疫调节、抗肿瘤和抗氧化等作用,是NF-κB信号通路的特异性抑制剂,具有良好的临床应用前景.CAPE抑制多种介质诱导的NF-κB通路活化,降低肿瘤坏死因子α和白细胞介素1β等促炎因子的浓度,其机制涉及阻滞p65核转录、抑制NF-κB与DNA结合等.本综述主要介绍近年来国内外关于CAPE基于NF-κB通路的抗炎免疫和抗肿瘤药理活性研究进展,以期对该化合物的进一步研究和应用提供参考.%Caffeic acid phenethyl ester (CAPE), a small-molecule selective inhibitor of NF-kB from propolis, exhibits anti-inflammatory, immuno-regulating, antitumor and antioxidant activities, with a good prospect of clinical application. CAPE inhibits TNF-α and activation of NF-κB induced by other media, and down-regulated concentrations of TNF-α, IL-1β and other proinflammatory cytokines by suppressing the transcriptional activity of p65 subunit, NF-κB-DNA binding action and other mechanisms. This review summarizes the progress in the anti-inflammatory, immuno-regulating and antitumor pharmacology activity of CAPE based on the inhibition of NF-κB in order to provide reference for further research and application of CAPE.