补体C5a在百草枯诱导急性肺损伤中的作用和机制

摘要

The lung is a major damage tissue in paraquat(PQ)-caused acute poisoned patients. Most deaths from acute PQ poisoning can be attributed to acute lung injury(ALI). Complement activa⁃tion product C5a causes inflammatory cells,such as neutrophils and macrophages,to accumulate into the lung and get activated. These activated inflammatory factors generate a large number of oxidants and inflammatory sequelae named "cytokine storm" to mediate ALI induced by PQ poison. The review focused on the role and mechanisms of complement C5a in PQ-induced ALI.%百草枯急性中毒受损最严重的是肺组织，而急性肺损伤是百草枯中毒致死的主要原因。补体活化产物C5a通过诱导炎症细胞如中性粒细胞和巨噬细胞等在肺部聚集、活化，进而产生过量的氧自由基和细胞因子等介导百草枯中毒后所导致的急性肺损伤。本文对补体C5a在百草枯诱导急性肺损伤中的作用和机制予以详细的综述。