三氧化二砷治疗早幼粒细胞白血病和毒性作用研究进展

摘要

三氧化二砷(As2O3)是一种古老的毒性药物,现已经作为一种新药被应用到临床.As2O3对多种肿瘤都显示出很好的治疗效果,尤其是对于急性早幼粒细胞白血病(APL)的治疗.研究表明,AS2O3对各个阶段的APL患者都起到缓解作用,AS2O3已被美国食品和药品监督管理局批准用于治疗APL.但As2O3的临床应用却由于其毒性作用受到限制,其中以心脏毒性作用最为显著.本文将对AS2O3抗治白血病作用和毒性作用做一综述,为AS2O3在临床上应用提供依据.%Arsenic trioxide (As2O3) has been considered a poison,which is also known as an old drug and has recently been re-introduced as a new medicine.As2O3 shows potent effect on many types of cancers,especially on a specific types of leukemia-acute promyelocytic leukemia (APL).This poison drug As2O3 is effective against all stages of APL and has been approved by the Food and Drug Administration (FDA) of the United States for the treatment of APL.However,the clinical use of As2O3 has been limited by its toxicities,especially cardiotoxicity.This review focuses on the therapeutic effect on APL and the side effect during treatment.