哺乳妇女停止喂奶后补充碳酸钙其骨骼骨密度未见明显的干预效果

摘要

目的 观察哺乳妇女骨骼骨密度的自我恢复状况,以及补充碳酸钙后对其骨骼骨密度的干预效果.方法 以湖北省武汉市郊区农村的120名健康哺乳期妇女为研究对象,随机分为两组:一组为补钙组(每日600 mg钙,碳酸钙),另一组为对照组,各60名.断奶时,使用双能X线吸收骨密度测定仪测量母亲腰椎和左髋等局部骨骼基线骨密度,并通过3d、24 h的膳食调查计算其平均每日钙摄入量,随即补钙(补钙组)或给予安慰剂(对照组),1年后再次测定相同部位的骨密度.结果 无论补钙组还是对照组,1年后研究对象腰椎和左髋的骨密度显著增加(P<0.05).补钙组与对照组之间比较,无论局部骨骼的骨密度还是骨转换指标差异均无统计学意义(P>0.05).结论 尽管我国产妇日摄入钙量较少.停止喂奶后1年内其腰椎和左髋骨密度仍明显增加;补充碳酸钙没有明显的干预效果.%Objective To observe the self-recovery of bone mineral density (BMD) in Chinese lactating women after weaning and the intervening efficacy with CaCO3 supplement on BMD.Methods One hundred and twenty healthy lactating women in the suburb of Wuhan, Hubei province were enrolled.They were randomly divided into 2 groups: the calcium supplement group (600mg CaCO3 daily) and the control group,with 60 women in each group.BMDs of the lumbar spine and the left hip were measured using dual-energy X-ray absorptionmetry immediately after weaning as the baseline.Calcium intake was calculated according to a 3-day food consumption questionnaire.Calcium or placebo was then initiated.BMDs of the same locations were re-measured one year later.Results Both in the calcium supplement group and in the control group,BMDs of the lumbar spine and the left hip increased significantly in all subjects (P ＜ 0.05).However, no significant difference was observed in BMD and bone turnover markers between the two groups ( P ＞ 0.05 ).Conclusion BMDs of the lumbar spine and the left hip increased significantly 1 year after weaning,although the daily intake of calcium was less in Chinese lactating women.CaCO3 supplement had no obvious benefit in intervention.