FRAX 评估南京地区中老年人群骨折风险的临床研究

摘要

Objective To evaluate the applicability of FRAX, the fracture risk assessment tool published by WHO, in senile population in Nanjing, to predict the fracture risk of senile population in different gender groups in Nanjing, and to discuss the effect of the hip BMD and previous fracture history on FRAX.Methods A total of 1383 senile people were grouped and the personal data including the risk factors were entered with the FRAX tool.The 10-year fracture probability of the hip and osteoporotic fractures was calculated.The results of FRAX in population with or without fracture history and the hip BMD were compared.Results The fracture risk of the female population in the next 10 years was much higher than that of the male population with the same age. Along with the increase of age, the probability of fracture risk of the hip and the whole body increased simultaneously.The fracture risk of the recurrence in next 10 years in population with previous fractures was much higher than that in people without fracture history.Except fracture history, the whole body and the hip fracture prediction showed no significant difference with or without BMD.Conclusion The FRAX tool can be effectively applied to assess the fracture risk of senile population in Nanjing.FRAX tool combined the hip BMD have clinical value in patients with or without previous fractures.%目的：评价WHO发布的骨折风险评估工具FRAX对南京地区中老年人群的适用性，预测本地区不同性别组中老年人群的骨折风险，讨论联合股骨颈BMD及既往骨折病史对于FRAX的影响。材料和方法对1383例南京地区中老年人群进行分组性研究。输入相关资料及FRAX工具中所包含的危险因素，计算10年内髋部骨折及全身骨质疏松性骨折风险概率，比较骨折既往病史人群及髋部BMD对FRAX预测结果影响。结果南京地区女性中老年人群未来10年内骨折风险远高于同年龄组男性；伴随年龄增大，髋部及全身骨折风险概率均同步增高；有既往骨折史的老年人群10年内再发骨折风险远高于无骨折史人群。除外既往骨折史，联合或不联合BMD后预测髋部及全身骨折结果无显著性差异。结论 FRAX工具可以对南京中老年人群骨折风险做出有效评估，联合髋部BMD值后获取的FRAX预测在既往骨折或未骨折患者中均具有临床应用价值。