不同性别及年龄因素对原发性骨质疏松症骨代谢指标、血清骨保护素及骨密度影响的研究

摘要

Objective To study the effect of different gender and age on bone metabolic indexes, serum osteoprotegerin, and bone mineral density in primary osteoporosis. Methods A total of 92 patients with primary osteoporosis were selected. According to gender, 92 patients were divided into male group (36 cases) and female group (56 cases). According to age, 92 patients were divided into 40⁃50⁃year⁃old group (38 cases), 50⁃60⁃year⁃old group (27 cases), 60⁃70⁃year⁃old group (17 cases), and over 70⁃year⁃old group (10 cases). Bone metabolic index (BGP and ALP), serum osteoprotegerin (OPG), and bone mineral density ( BMD) were detected in patients of the different gender and age groups Statistical analysis was performed on the change trend of every index. Results The levels of BGP, ALP, and OPG were lower in male patients than those in females (P<0�05), but the average BMD of the lumbar spine and the right femoral neck was higher than that in females (P<0�05). With the increase of age, levels of BGP, ALP, and OPG increased (P<0�05), but BMD of the lumbar spine and the right femoral neck decreased (P<0�05). Conclusion Gender and age are important factors to affect bone metabolic index, serum osteoprotegerin, and BMD in patients with primary osteoporosis. By analysis of the impact factors we can provide the reference for the prevention and control of the disease.%目的：研究不同性别及年龄因素对原发性骨质疏松症骨代谢指标、血清骨保护素及骨密度的影响。方法选择92例原发性骨质疏松症患者为研究对象，根据性别的不同，将本组92例患者分为男性组36例和女性组56例；根据年龄的不同，将92例患者按10岁为一年龄段分组，分为40～50岁组38例，50～60岁组27例，60～70岁组17例，＞70岁组10例。分别对不同性别、不同年龄组患者的骨代谢指标（ BGP、ALP）、血清骨保护素（ OPG）及骨密度（ BMD）进行检测，统计分析不同性别、年龄阶段患者各指标水平的变化趋势。结果男性组患者平均BGP、ALP、OPG指标水平均低于女性组（P均＜0�05），平均腰椎正位、右股骨颈BMD均高于女性组（P均＜0�05）。随着患者年龄的增加， BGP、ALP、OPG指标水平逐渐升高（P＜0�05）；同时，随着患者年龄的增加，腰椎正位、右股骨颈BMD指标值逐渐下降（P＜0�05）。结论性别及年龄是影响原发性骨质疏松症患者的骨代谢指标、血清骨保护素及骨密度指标水平的重要因素，通过其影响机制的分析可为该病的防控提供参考依据。