Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in Asia, which de-serves more research group participants. However, statistical and technical biases can easily lead to miscon-ception and false directions. We expressed our interest and opinion on the article based on a prospective du-al-tracer [18s F-fluorodeoxyglucose (FDG) and 11C-acetate] PET/CT study in the evaluation of primary and metastatic HCC. The opinions were stated in the light of some important technical issues including statistics, diagnostic criteria and sampling differences for the detection of small primary HCC, metastatic HCC and cholangiocarcinoma.%肝细胞癌是亚洲地区发病率最高的肿瘤之一,因此有众多的研究涉及肝细胞癌.然而,在研究中所用统计学方法和技术等不当易得出不正确的概念和结论.作者就已发表在美国<核医学杂志>上的<18F-FDG及11C-乙酸盐PET/CT诊断原发及转移性肝细胞癌的前瞻性研究>一文提出了一些不同观点,希望这方面的研究者能掌握正确的统计学方法、诊断标准及样本人选标准.
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