MicroRNA-21对肿瘤生物学行为的影响及其分子靶向成像与治疗的研究进展

摘要

MicroRNAs (miRNAs)是一类长18～27个核苷酸的单链RNA分子,能调控其靶基因相关信号通路,发挥肿瘤抑癌基因或癌基因的功能,从而影响癌症的发生发展.MicroRNA-21(miR-21)是人类细胞中早期发现的miRNAs之一,在多种癌症中处于明显高表达状态,其异常表达与癌症的发生发展密切相关.该文对miR-21在恶性肿瘤发生发展、转移、治疗及分子显像等方面的研究进展进行综述.%MicroRNAs (miRNAs) is a set of single-stranded RNA molecules with a length of 18-27 nucleotides,which can regulate the genesis and development of tumor and play the role of tumor suppres sor or oncogenic function by regulating its targeted gene-related signaling pathways.MicroRNA-21 (miR-21)is one of the early discovered miRNAs in human cells,and its expression is significantly elevated in a majority of cancers.The abnormal expression of miR-21 is closely associated with pathogenesis and progression of cancers.In this review,the progress of miR-21 in the occurrence,development,metastasis,treatment and molecular imaging of malignant tumors are summarized.