3种撞击器测定异丙托溴铵气雾剂体外沉积性质的比较

摘要

目的:通过测定异丙托溴铵气雾剂的动态粒径分布,评估其体外沉积性质,并评价不同测定方法的优缺点.方法:分别采用二级撞击器(TI)、安德森撞击器(ACI)和新一代撞击器(NGI)测定异丙托溴铵气雾剂的动态粒径分布.结果:采用TI方法研究气雾剂的肺部沉积,该方法简单易行,但仅能预估肺部沉积量和喉部沉积量,很难进行进一步分析;尽管级联撞击器(CI)方法操作步骤繁杂、耗时,但该方法不仅能得到药物的微细粒子剂量,还能得到气雾剂的空气动力学粒径分布信息.此外,实验结果亦表明ACI与NGI在测定气雾剂的空气动力学粒径分布方面无显著性差异,但NGI的层级间损失更少,并且操作更简便,因此,相比于ACI,NGI方法更具优越性.结论:与二级撞击器相比,级联撞击器方法在评价气雾剂的质量时更为完善.%Objective:To evaluate and compare the characters of ipratropium bromide aerosol in vitro deposition with three different impactors.Methods:To measure the particle size of ipratropium bromide with twin-stage impactor,ACI and NGI.Results:Using twin-stage impactor is simple,but it can only predict the deposition amounts of lung and throat.Although cascade impactor(CI) method is featured with complicated and time-consuming,it can not only acquire the fine particle dose,but also the aerodynamic particle size distribution of aerosol.Furthermore,the tests show that the methods of ACI and NGI have no significant difference and the wall loss of NGI is less than ACI.So,NGI is a better method than ACI.Conclusion:CI method is more scientific than TI method when evaluating the quality of aerosol.