目的:观察盐酸羟考酮注射液在下腹部手术全麻苏醒期急性疼痛的疗效及不良反应情况.方法:选择下腹部手术患者120例,随机分为3组:羟考酮组(Q组)、地佐辛组(D组)和吗啡组(M组),每组40例,分别于手术结束前30 min静脉注射羟考酮0.1 mg· kg-1、地佐辛0.1 mg·kg-1和吗啡0.1 mg· kg-1.观察并记录3组患者停药后苏醒时间、拔管时间、术后疼痛视觉模拟评分(visual analogue scale,VAS)、警觉/镇静评分(OAA/S)、苏醒期躁动(emergence agitation,EA)、拔管后10 min的血气分析和药物不良反应(呼吸抑制、恶心、呕吐等).结果:3组患者一般资料无统计学差异.3组患者的术后苏醒时间、拔管时间、EA、拔管后10 min的血气分析、呼吸抑制、恶心、呕吐无统计学意义.Q组术后VAS评分优于其他2组,D组OAA/S评分低于M组(P＜0.05).结论:手术结束前30 min给予羟考酮注射液0.1 mg· kg-1可有效预防下腹部全麻术后苏醒期急性疼痛的发生,且效果优于地佐辛和吗啡.%Objective:To observe the efficacy and adverse reactions of oxycodone hydrochloride injection for acute pain during anesthesia recovery period after lower abdominal surgery under general anesthesia.Methods:One hundred and twenty patients receiving lower abdominal surgery were randomly divided into three groups:oxycodone group (group Q),dezocine group (group D) and morphine group (group M),40 cases in each group.The patients were intravenously given oxycodone 0.1 mg· kg-1,dezocine 0.1 mg· kg-1 and morphine 0.1 mg· kg-1respectively 30 min before the end of surgery.The awakening time,extubation time,postoperative pain visual analogue scale (VAS),alertness/sedation score (OAA/S),agitation emergence (EA),blood gas analysis 10 min after extubation and adverse drug reactions (respiratory depression,nausea and vomiting) were observed and recorded.Results:There was no statistical difference in the general characteristics among the three groups.The awakening time,extubation time,EA score,blood gas analysis 10 min after extubation,and frequencies of respiratory depression,nausea and vomiting were not statistically different among the three groups.The postoperative VAS score of group Q was better than those of the other two groups.The OAA/S score of group D was lower than that of group M (P ＜ 0.05).Conclusion:Giving oxycodone injection 0.1 mg· kg-1 30 min before the end of surgery can effectively prevent acute pain after lower abdominal surgery under general anesthesia,and the effect is better than dezocine and morphine.
展开▼
