Objective To understand the antimicrobial susceptibility of the bacteria in our hospital, and guide the application of antibiotics.Methods In the Luozhuang center hospital of Linyi in 2012, the drug resistance of clinically isolated strains was monitored, and their antimicrobial susceptibility were analyzed by disc diffusion method recommended by CLSI, using WHONET5.3 software to analyze the results.Results According to the moni-toring programme, the result of susceptibility test of 780 strains of bacteria to antimicrobial agents were obtained, in-cluding 239 strains of gram-positive bacteria, accounting for 30.6%;541 strains of gram-negative bacteria, account-ing for 69.4%.Except for pseudomonas aeruginosa, drug sensitive rate of all gram-negative bacillus to carbapenems were over 85.7%, those of piperacillin-tazobactam were more than 79.6%;those of all the staphylococcus aureus to vancomycin were 100.0%.Methicillin-resistant staphylococcus aureus(MRSA)detection rate was 51.1%, sensitive rate of MRSA to chloromycetin was 80.0%, with resistance to other antibiotics;the sensitive rate of faecium and fae-calis to vancomycin and linezolid were the highest (96.6%,100.0%;100.0%,100.0%).Conclusion The sensi-tive rates of klebsiella pneumoniae, escherichia coli, acinetobacter and enterobacter to carbapenems were higher, but the drug resistence rate of pseudomonas aeruginosa to it was higher.The sensitive rates of staphylococcus aureus to vancomycin, linezolid and teicoplanin were higher.%目的：了解该院细菌对抗菌药物的敏感性，指导临床抗菌药物合理应用。方法监测该院2012年临床分离菌株的耐药性，以美国临床和实验室标准协会（ CLSI）推荐的纸片扩散法测定其抗菌药物敏感性，用WHONET5.3软件分析结果。结果按照监测方案，共获得780株细菌对抗菌药物敏感性结果，其中革兰阳性菌239株，占30.6％；革兰阴性菌541株，占69.4％。除绿脓杆菌外，所有革兰阴性杆菌对碳青霉烯类药物敏感率均在85.7％以上，哌拉西林他唑巴坦79.6％以上；所有葡萄球菌对万古霉素100.0％敏感，耐甲氧西林金黄色葡萄球菌（ MRSA）检出率为51.1％，MRSA对氯霉素的敏感率为80.0％，对其他药物均较耐药；屎肠球菌和粪肠球菌对万古霉素和利奈唑胺最敏感（96.6％，100.0％；100.0％，100.0％）。结论肺炎克雷伯菌、大肠埃希菌、鲍曼不动杆菌、肠杆菌属对碳青霉烯类敏感率较高，但铜绿假单胞菌对其耐药率较高。葡萄球菌属对万古霉素、利奈唑胺、替考拉宁敏感率均较高。
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