Background Clinical outcome in patients with severe traumatic brain injury ( TBI) depends on both primary and seconda-ry brain injuries.Neuroinflammation is an important secondary mechanism, which occurs by releasing interleukins ( ILs ) .Increased levels of ILs may affect clinical outcome following TBI.OBJECTIVE This study aimed to determine the relationship between the serum levels of interleukins 6, 8 and 10 and clinical outcome in patients with severe TBI 6 months after injury.PATIENTS And METHODS In a descriptive-analytical study, 44 patients with GCS≤8 ( Glasgow coma scale) and age≥14 years were included.Their blood samples were collected at first 6 hours after injury.Clinical outcome was determined based on GOS ( Glasgow Outcome Scale) at 6 months after head injury.Serum levels of interleukins 6, 8 and 10 were measured using the ELISA method.Spearmanˊs rho, independent T-Test, and Mann-Whitney Test were used for data analysis.RESULTS Comparing the serum levels of interleukins in two groups with favorable and unfavorable clinical outcomes showed that the mean serum levels of interleukins 6 and 8 in group with favorable outcome was 85.2 ±51.6 and 52.2 ±31.9, respectively lower than those of group with unfavorable outcome with 162.3 ±141.1 and 173.6 ±257.3 (P<0.03) and (P<0.01).CONCLUSIONS Increased serum levels of interleukins 6 and 8 as a predictive marker might be associated with unfa-vorable clinical outcome in patients with severe TBI.
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