Objective To acquire related data of a deep saturation dive which approaches the depth limit in terms of physiology,and to further improve medical service for such dives.Methods A series of simulated heliox saturation dives (saturation depths,65-480 m) were conducted by 9 naval divers.During the experiments,modified diving procedures,intensified medical surveillance measures,targeted medical intervention and performance evaluation were applied to ensure the success of the dive.Results Following research results were obtained:the decompression profile based on the bubble theory was developed and applied in a series of diving experiments ; the superiority of urine metabonomics in full-scale and noninvasive medical detection of divers at high pressure was demonstrated; pharmacological intervention was used to alleviate harmful loads; and effective identification means were established to distinguish pressure susceptible people.Conclusions The research results obtained from this project would enrich and deepen intimate knowledge on hyperbaric physiology and would be a good guidance for better medical supports in deep saturation dives.%目的 获取人体在高压耐受极限区域的潜水实验数据,完善相关医学保障措施.方法 由9名海军潜水员参与饱和深度65 ~480 m的系列氦氧模拟饱和潜水,采用改进的潜水程序、强化的医学监护措施和针对性的医学干预完善医学保障措施,并进行潜水员能力评价.结果 首次成功应用了建立在气泡学说基础上的我国饱和减压方案,证实了代谢组学在高气压环境下全面、无创性医学监护的优势,成功运用药物干预减轻了损伤性负荷,建立了压力敏感型人员的有效鉴别手段.结论 该研究取得的成果将丰富和深化高气压生理学内涵,为大深度潜水实践提供有效指导.
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